ABSTRACT
The study was conducted in Afikpo South Local Government covering a total area of 331.5km2. Remote sensing and Geographic Information System (GIS) were integrated with multicriteria analysis to delineate the flood vulnerable areas. Seven criteria were considered; rainfall, runoff, slope, distance to drainage, drainage density, landuse and landcover, and soil. The various criteria were fit into fuzzy membership classes based on their effect in causing flood. The fuzzy members of all criteria were then overlaid to generate the flood vulnerability map. The result of the flood vulnerability map shows that very low vulnerable zones cover 86.7% of the total area, low vulnerable zones cover 1.6% of the total area, moderate vulnerable zones cover 2.17% of the total area, highly vulnerable zones cover 2.3% of the total area while very highly vulnerable zones cover 7.3% of the total area. Built up was used as a measure of the effect of flooding on human lives and properties in Afikpo South Local Government. Built up covers a total area of 38.6km2. Over sixty eight (69.8%) of built up lies in very low vulnerable zone, 3% lies in low vulnerable zone, 3.7% lies in moderate vulnerable zone, 0.6% lies in highly vulnerable zone and 17.9% lies in very highly vulnerable zone. The study provides information on target areas that may be affected by flood in Afikpo South Local Government. This information is useful for decision making on flood early warning and preparedness as well as in mitigation preparedness within Afikpo LGA.
ABSTRACT
Background: Reports of adverse drug reactions (ADR) in the era of increasing uptake of antiretroviral drugs particularly in Sub Saharan Africa and especially in Nigeria have been on the rise. Aim: We set out to collate and characterize the pattern of adverse drug reactions in patients on antiretroviral drugs in our treatment centre. Study Design: Retrospective Cross sectional study Place and Duration of Study: The study was carried out at the APIN Centre, Jos University Teaching Hospital, Plateau State, North Central Nigeria from July 2010 to December 2012. Methodology: We reviewed the case files and data base entries of 215 patients attending our treatment centre. These are patients who had reported cases of adverse drug reactions. We took note of demographic profiles of the patients, the medical history as well as the different types of antiretroviral drugs the patients were taking. The types of adverse drug reactions and offending drugs were noted and categorized using descriptive statistics. Results: Out of 215 case files and databases of patients in which there were reports of adverse drug reactions, 80 (37.2%) were male and 135 (62.8%) were female. Almost thirty two percent (31.6%) of the patients were on Zidovudine/Lamivudine/Nevirapine (AZT/3TC/NVP), 14.9%on Zidovudine/Lamivudine/Tenofovir/Lopinavir/ritonavir (AZT/3TC/TDF/LPV/r), 13.5% on Stavudine/Lamivudine/Nevirapine (D4T/3TC/NVP). Anemia was the most common ADR representing 23.4% of all ADRs and 29.3% of all ADRs were associated with Zidovudine. Conclusion: Our study shows that in antiretroviral treatment centre such as our own, healthcare providers/practitioners should take particular note of troubling adverse drug reactions such as anaemia. Healthcare providers/practitioners should particularly have in place alternative treatment regimens as these adverse drug reactions may be potential cause of medication non adherence which in the long run lead to treatment failure.